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Immunological Mechanisms Related to Clinical Responsiveness Differ Between Methotrexate Monotherapy and Methotrexate and anti-TNFá Co-Treatment in Rheumatoid Arthritis


Friday, November 20, 2009


Theo van den Broek, M.D.

Research Fellow
The University of Arizona Arthritis Center

Participants should be able to:
Understand that the anti-TNFá treatment is not merely focused on TNFá suppression
Recognize that the clinical response by Methotrexate treatment or when in combination with an anti-TNFá agent is due to different mechanisms
Understand that Methotrexate treatment involves aspects of immune tolerance and regulation while anti-TNFá/Methotrexate treatment downregulates the pro-inflammatory aspects of Teff and APC